1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines

✍ Scribed by Giuliana Biagi; Irene Giorgi; Oreste Livi; Clementina Manera; Valerio Scartoni

• Publisher: Journal of Heterocyclic Chemistry
• Year: 1999
• Tongue: English
• Weight: 301 KB
• Volume: 36
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570360514

✦ Synopsis

Abstract

Some new 1,2,3‐triazolo[4,5‐e]‐1,2,4‐triazolo[3,4‐c]pyrimidmes were prepared starting from the corresponding 1,2,3‐triazolo[4,5‐d]pyrimidines via the formation of the 1,2,4‐triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, triethyl orthoacetate and triethyl orthobenzoate to give the expected tricyclic derivatives 7, 8 and 9. Intramolecular cyclization of the ethoxycarbonylhydrazino derivatives 10 gave the tricyclic compounds 11 bearing an hydroxyl group in the 3 position. The v‐triazolo‐s‐triazolopyrimidine derivatives were tested towards the A~1~ and A~2A~ adenosine receptors in binding assays, but they did not show any receptor affinity.