𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New 1,2,3-triazolo[4,5-e]1,2,4-triazolo[4,3-c]pyrimidine derivatives II

✍ Scribed by Giuliana Biagi; Irene Giorgi; Oreste Livi; Federica Pacchini; Valerio Scartoni

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
32 KB
Volume
39
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The 7‐chloro‐3‐(2‐chlorobenzyl)‐ and 7‐chloro‐3‐(2‐fluorobenzyl)‐1,2,3‐triazolo[4,5‐d]pyrimidines (1 and 4), by nucleophilic replacement with some hydrazides, gave the corresponding 7‐hydrazidoderivatives (2a‐e and 5a‐e). These, by heating in Dowtherm, underwent an intramolecular cyclization to form the new tricyclic 7‐substituted‐3‐(2‐chlorobenzyl)‐ and 3‐(2‐fluorobenzyl)‐1,2,3‐triazolo[4,5‐e]1,2,4‐triazolo[4,3‐c]pyrimidines (3a‐d and 6a‐d). The 7‐hydrazino‐3‐(2‐chlorobenzyl)‐ and 7‐hydrazino‐3‐(2‐fluorobenzyl)‐triazolo‐pyrimidines (9a and 9b) were also prepared via the corresponding mercapto (7a and 7b) and thiomethyl (8a and 8b) derivatives.

📜 SIMILAR VOLUMES

1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4
1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines
✍ Giuliana Biagi; Irene Giorgi; Oreste Livi; Clementina Manera; Valerio Scartoni 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 301 KB 👁 1 views

## Abstract Some new 1,2,3‐triazolo[4,5‐__e__]‐1,2,4‐triazolo[3,4‐__c__]pyrimidmes were prepared starting from the corresponding 1,2,3‐triazolo[4,5‐__d__]pyrimidines __via__ the formation of the 1,2,4‐triazole ring. Thus suitable hydrazino derivatives 6 were condensed with triethyl orthoformate, tr

New 1,2,3-triazolo[4,5-d]1,2,4-triazolo[
New 1,2,3-triazolo[4,5-d]1,2,4-triazolo[3,4-b]pyridazine derivatives II
✍ Giuliana Biagi; Fabio Ciambrone; Irene Giorgi; Oreste Livi; Valerio Scartoni; Pi 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 54 KB 👁 1 views

## Abstract New tricyclic 1,2,3‐triazolo‐1,2,4‐triazolo‐pyridazine derivatives, bearing a methyl substituent on the 1,2,3‐triazole ring, were prepared as potential biological agents. __N__‐Methylation of dimethyl 1,2,3‐triazole‐4,5‐dicarboxylate allowed synthesis of the isomeric 1‐methyl‐4,7‐dihydr