Synthesis of (2S,5S)-bishydroxymethyl-(3R,4R)-bishydroxypyrrolidine from D-mannitol
โ Scribed by Tony K.M. Shing
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 273 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
A catalytic deuteration of protected 3,4-dehydro-L-proline using RuCI2(PPh3) 3 followed by RuO~-oxidation gave a 3,4-dideuterated L-pyroglutamic acid derivative which is considered to be a promising precursor for various deuterated amino acids. The present study demonstrates a stereoselective reduct
Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form. Some commentS and studies regarding pyrrolidine ring closure (key step) are also qorted. Over the last few years, interest in pyrrolidine-type derivatives has grown considerably, from b