Enantiospecific syntheses of 2S,3R,4R,5S-trihydroxypipecolic acid, 2R,3R,4R,5S-trihydroxypipecolic acid, 2S,4S,5S-dihydroxypipecolic acid, and bulgecinine from D-glucuronolactone
✍ Scribed by B.P. Bashyal; H.-F. Chow; G.W.J. Fleet
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 273 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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Epoxy ring opening of 2 and 2 with [ l -1 4 C ] hexadecyl copper lo gave respectivezy t h e analog 4 of agaric acid trimethyl e s t e r and methy2 b -1 4 ~J a g a r i c a t e 5, which-was hydrolysed t o -& by Zithium hy-&oxide i n I, 2-dimethoxyethane (DME). Epoxy ring trans opening of -2 with d i
The condensation of (1 R,2S) or (lS,2S)-N,N'-dimethyI-l-phenylpropane-l 2-diamines with aldehydes gives respectively two diastereorneric 2-alkyl-l,3,4-trimethyI-S-phen limidazolidines. At thermodynamical equilibrium the major isomer in the erythro series is this one where t f ! e substituents at pos