Synthesis of (2S,4S,5S)-5-hydroxy-4-meth
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Claus Herdeis; Eberhard Heller
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Article
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1997
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Elsevier Science
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English
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4S,5S)-5-hydroxy-4-methylpiperidine-2-one 4, readily available from Sglutamic acid, serves as a starting material for the synthesis of (2S,4S,5S)-5-hydroxy-4methylpipecolic acid 12. The key step of this reaction sequence is the chemoselective methylenation of the amide carbonyl group of 6 with dimet