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Synthesis of (2R,4S,5S)-5-acetamido-4-hydroxy-pipecolinic acid as a potential inhibitor of sialidases

✍ Scribed by Keith Clinch; Andrea Vasella; R. Schauer


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
263 KB
Volume
28
Category
Article
ISSN
0040-4039

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Synthesis of (2S,4S,5S)-5-hydroxy-4-meth
✍ Claus Herdeis; Eberhard Heller πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 487 KB

4S,5S)-5-hydroxy-4-methylpiperidine-2-one 4, readily available from Sglutamic acid, serves as a starting material for the synthesis of (2S,4S,5S)-5-hydroxy-4methylpipecolic acid 12. The key step of this reaction sequence is the chemoselective methylenation of the amide carbonyl group of 6 with dimet