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Synthesis of (3S, 4S)-4-hydroxy-2, 3, 4, 5-tetrahydropyridazine-3-carboxylic acid, component of luzopeptin A.

✍ Scribed by Christine Greck; Laurent Bischoff; Jean Pierre Genêt


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
290 KB
Volume
6
Category
Article
ISSN
0957-4166

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Stereoselective synthesis of (2S,3S,4R,5
✍ Makoto Oba; Tsutomu Terauchi; Jun Hashimoto; Tomohiro Tanaka; Kozaburo Nishiyama 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 227 KB

A catalytic deuteration of protected 3,4-dehydro-L-proline using RuCI2(PPh3) 3 followed by RuO~-oxidation gave a 3,4-dideuterated L-pyroglutamic acid derivative which is considered to be a promising precursor for various deuterated amino acids. The present study demonstrates a stereoselective reduct