The synthesis of 46 derivatives of (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol is reported (Scheme 1 and Fig. 3), and their inhibitory activities toward a-mannosidases from jack bean (B) and almonds (A) are evaluated (Table ). The most-potent inhibitors are (2R,3R,4S)-2-{[([1,1'-biphenyl]-4-ylmet
Synthesis of 1s,2r,3s,4r,5r-methyl[2,3,4-trihydroxy-5-(hydroxymbthyl)cyclopentyl]amine: a potent α-mannosidase inhibitor
✍ Scribed by Robert A. Farr; Norton P. Peet; Nohinder S. Fang
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 296 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Single-crystal X-ray study T = 293 K Mean '(C±C) = 0.005 A Ê Disorder in main residue R factor = 0.047 wR factor = 0.124 Data-to-parameter ratio = 15.9 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
At 173 K, the ®ve-membered ring of the title compound, C 22 H 26 N 2 O 5 , has an envelope conformation. The amine group is involved in both intramolecular and intermolecular hydrogen bonds, the latter linking the molecules into centrosymmetric dimers. ## Experimental The title compound was prepa