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Chemical Modification of the α-Mannosidase Inhibitor Mannostain A: Synthesis of a Potent Inhibitor 1L-(1,2,3,5/4)-5-Amino-4-O-methyl-1,2,3,4-cyclopentanetetrol

✍ Scribed by Seiichiro Ogawa; Takayuki Morikawa


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
166 KB
Volume
2005
Category
Article
ISSN
1434-193X

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In order to elucidate the essential core structure of potent the five stereoisomers thus obtained for the six glycosidases has demonstrated the 2/3,4,5) and (1,2,3,4,5/0) isomers α-mannosidase inhibitors, e.g. mannostatin A, 5-amino-5-Cmethyl-1,2,3,4-cyclopentanetetrols 4-8 were designed and to be m