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Synthesis of 2,4- and 2,5-Disubstituted Oxazoles via Metal- Catalyzed Cross-Coupling Reactions

✍ Scribed by Carla M. Counceller; Chad C. Eichman; Nicolas Proust; James P. Stambuli

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
180 KB
Volume
353
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

The rapid synthesis of 2,4‐ and 2,5‐disubstituted oxazoles via metal‐catalyzed cross‐coupling reactions is reported. The 4‐ or 5‐position of the corresponding 4‐ or 5‐halogenated 2‐butylthiooxazoles was successfully functionalized via Suzuki–Miyaura, Sonogashira and Stille cross‐coupling reactions. The 2‐position of the 2‐butylthiooxazoles obtained was further coupled to various organozinc reagents through palladium‐ or nickel‐mediated cross‐coupling reactions.

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