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Synthesis of 2-phosphinoxidomethyl- and 2-phosphonomethyl glutaric acid derivatives

✍ Scribed by Kálmán Harsányi; György Domány; István Greiner; Henrietta Forintos; György Keglevich

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
72 KB
Volume
16
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Michael addition of the corresponding anions derived from diphenylphosphine oxide, dialkylphosphites, and a cyclic phosphite to α‐methylene‐glutaric esters (1) afforded the title compounds (2–6). Double debenzylation of 2‐phosphono glutaric esters 4b and 5a by catalytic hydrogenation under the appropriate conditions gave the correspon‐ ding diacides 8 and 9, respectively. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:562–565, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20142

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