๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors.

โœ Scribed by Hideyuki Kanno; Ken Osanai; Tatsuya Nishi; Minoru Iino; Shin-ichi Katakura; Taketoshi Furugohri; Yoshifumi Watanabe

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
174 KB
Volume
6
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.

โœฆ Synopsis

A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.

๐Ÿ“œ SIMILAR VOLUMES

Design, synthesis and biological evaluat
Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors
โœ Ying Yang; Lei Shi; Yang Zhou; Huan-Qiu Li; Zhen-Wei Zhu; Hai-Liang Zhu ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 321 KB

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical