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Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives

✍ Scribed by Hideyuki Kanno; Ken Osanai; Taketoshi Furugohri; Yoshifumi Watanabe


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
245 KB
Volume
6
Category
Article
ISSN
0960-894X

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πŸ“œ SIMILAR VOLUMES


Synthesis and evaluation of 2-(biphenylm
✍ Hideyuki Kanno; Ken Osanai; Tatsuya Nishi; Minoru Iino; Shin-ichi Katakura; Take πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 174 KB

A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.