Synthesis and evaluation of 2-(biphenylm
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Hideyuki Kanno; Ken Osanai; Tatsuya Nishi; Minoru Iino; Shin-ichi Katakura; Take
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Article
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1996
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Elsevier Science
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English
β 174 KB
A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme interactions of the most potent compound 3a, with a thiazolylacetic acid group at the P2' position, was evaluated by a computer analysis.