2',3'-Dideoxy-3'-hydroxymethylcytidine (1) has been synthesized via stereoseleetive Rhcatalyzed hydroformylation of 2',3'-didehydro-2',3'-dideoxycytidine 3b. This synthesis incorporates the first successful hydroformylation of a nucleoside olefin.
Synthesis of 2•,3•-Dideoxy-3•-C-hydroxymethylcytidine Phosphonomethyl Derivatives
✍ Scribed by Annika Niklasson; Ingemar Kvarnström; Björn Classon; Bertil Samuelsson
- Publisher
- Springer
- Year
- 1998
- Weight
- 233 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1433-1373
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5 0 -O-Benzoyl-2,3 0 -anhydrothymidine. 60% Methanol in water, retention time 13.1 min. \* 2 0 ,3 0 -Dideoxy-2 0 ,3 0 -didehydrothymidine. Solvents: A -water; B -methanol. Program: 0-40% B/A in 40 min, retention time 33.9 min. TLC was carried out on Silufol plates (Czech Republic). \* 5 0 -O-Benzo
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