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Synthesis of tritium-labeled 2′,3′-dideoxy-2′,3′-didehydrothymidine

✍ Scribed by G. V. Sidorov; N. F. Myasoedov; M. V. Jasko; Yu. S. Skoblov

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 115 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1287

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✦ Synopsis

5 0 -O-Benzoyl-2,3 0 -anhydrothymidine. 60% Methanol in water, retention time 13.1 min. * 2 0 ,3 0 -Dideoxy-2 0 ,3 0 -didehydrothymidine. Solvents: A -water; B -methanol. Program: 0-40% B/A in 40 min, retention time 33.9 min.

TLC was carried out on Silufol plates (Czech Republic).

* 5 0 -O-Benzoyl-2,3 0 -anhydrothymidine in chloroformethanol (95:5 v/v) solvent system, R f ¼ 0:35. * 2 0 ,3 0 -Dideoxy-2 0 ,3 0 -didehydrothymidine chloroformethanol (9:1 v/v) solvent system, R f ¼ 0:28. Figure 1 NMR spectrum of 2 0 ,3 0 -dideoxy-2 0 ,3 0 -didehydrothymidine ('cold' synthesis) in D 2 O. AMX III-400 (Bruker) spectrometer with the 400 MHz operating frequency for 1 H.

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