A simple four-stage conversion of 2-1nethyl-4(5>nitroimidazole to 2-methyl-4(5)-nitr0['~N""]imidazole is reported. The method consists in N-nitration of the initial compound to ?-methyl-1,4-dinitroimidazole, treating the latter with ["Nlglycine and N-dealkylation of the obtained (~-rnethyl-4-nitro[~
Synthesis of (2-methyl-4-nitro-1-[15N1]imidazolyl)acetic acid
✍ Scribed by Jerzy Suwinski; Wojciech Szczepankiewicz
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 161 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
1,4‐Dinitro‐2‐methylimidazole reacts under mild conditions with glycine to yield (2‐methyl‐4‐nitro‐1‐imidazolyl)acetic acid. The use of [^15^N]glycine gives a product having a labelled nitrogen in 1 position of 4‐nitroimidazole.
📜 SIMILAR VOLUMES
## Abstract The increasing clinical importance of drug‐resistant pathogens has lent additional urgency to antimicrobial research. Various 5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐4__H__‐1, 2, 4‐triazoles (**4a—6f**) were synthesized and tested __in vitro__ for their antibacterial and antifungal activities
## Abstract A series of substituted __N__‐(4‐substituted‐benzoyl)‐__N__‐[3‐(1‐methyl‐1__H__‐imidazol‐2‐yl)propyl]amines (**13**) and __N__‐arylsulfonyl‐__N__‐[3‐(1‐methyl‐1__H__‐imidazol‐2‐yl)propyl]amines (**14**) were prepared from the reaction of 3‐(1‐methyl‐1__H__‐imidazol‐2‐yl)propan‐1‐amine (