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Synthesis of 2-Fluoro- and 6-Fluoro-(2 S ,3 R )-(3,4-dihydroxyphenyl)serine as Potential in Vivo Precursors of Fluorinated Norepinephrines

โœ Scribed by Herbert, Brian; Kim, In Ho; Kirk, Kenneth L.


Book ID
127378528
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
79 KB
Volume
66
Category
Article
ISSN
0022-3263

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A convenient synthesis of 2-fluoro- and
โœ In Ho Kim; Kenneth L Kirk ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 58 KB

Ring-fluorinated b-hydroxy a-amino methyl esters 3b,c were synthesized enantioselectively using Sharpless asymmetric aminohydroxylation. These were converted to 2-fluoro-and 6-fluoro-(2S,3R)-threo-(3,4-dihydroxyphenyl)serine 1b,c using our previously published procedure.