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Synthesis of 2- and 6-fluoro analogues of threo-3-(3,4-dihydroxyphenyl)serine (2- and 6-fluoro-threo-DOPS)

โœ Scribed by Bang-Hua Chen; Jun-ying Nie; Mona Singh; Victor W. Pike; Kenneth L. Kirk

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
932 KB
Volume
75
Category
Article
ISSN
0022-1139

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๐Ÿ“œ SIMILAR VOLUMES

A convenient synthesis of 2-fluoro- and
A convenient synthesis of 2-fluoro- and 6-fluoro-(2S,3R)-threo-(3,4-dihydroxyphenyl)serine using Sharpless asymmetric aminohydroxylation
โœ In Ho Kim; Kenneth L Kirk ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 58 KB

Ring-fluorinated b-hydroxy a-amino methyl esters 3b,c were synthesized enantioselectively using Sharpless asymmetric aminohydroxylation. These were converted to 2-fluoro-and 6-fluoro-(2S,3R)-threo-(3,4-dihydroxyphenyl)serine 1b,c using our previously published procedure.