New Convenient Synthesis of Fluorinated Penciclovir Analogues 9-(4-Fluoro-3-hydroxymethylbutyl) Guanine (FHBG) (VII) and 2-Amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) Purine (6-Fluoropenciclovir) (XII).

The synthesis of a new probe for PET ima

The synthesis of a new probe for PET imaging reporter gene HSV1-tk: 2-amino-6-[18F] fluoro-9- (4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)

✍ Hancheng Cai; Duanzhi Yin; Lan Zhang; Yongxian Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

The one step radiosynthesis of 2-amino-6-[ 18 F]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[ 18 F]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[ 18 F]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [ 18 F]KF and isolated by a silica Sep-Pak cartridge. Th