Synthesis of 2-chloro-4-nitrophenyl α-l-fucopyranoside: a substrate for α-l-fucosidase (AFU)
✍ Scribed by Guofeng Gu; Yuguo Du; Hongyan Hu; Cheng Jin
- Book ID
- 108309479
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 210 KB
- Volume
- 338
- Category
- Article
- ISSN
- 0008-6215
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📜 SIMILAR VOLUMES
In a previous papeti in this series, we described the synthesis of L-fucosyldisaccharides having sulfate groups at C-3 or C-4. Such r\_-fucosyl-oligosaccharides occur naturally as a part of the structure of fucoidan, a sulfated L-fucose polysaccharide, know to possess anticoagulant acticity 3,4 This
Synthesis of methyl 2-O-alpha-L-fucopyranosyl-alpha-L-fucopyranoside 3- and 4-sulfate was accomplished through the use of a key glycosyl donor, methyl 2,3,4-tri-O-benzyl-1-thio-beta-L-fucopyranoside, with methyl 2,3-O-isopropylidene-alpha-L-fucopyranoside and methyl 4-O-acetyl-3-O-benzyl-alpha-fucop