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Synthesis of [2-14C]-2′-deoxycytidine-3N-cyanoborane

✍ Scribed by Bruce S. Burnham; Steven D. Wyrick; Iris H. Hall; Anup Sood; Bernard F. Spielvogel

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
193 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Synthetic nucleosides (e.g., 5‐fluorouracil, 6‐mercaptopurine) are used extensively as antineoplastic drugs. Recent research in boron chemistry has lead to the development of a series of amine‐boranes that possess significant antineoplastic activity. The agents may also be useful in boron neutron capture therapy (BNCT), therefore giving the compounds a dual mechanism of cytotoxic action. Herein is a report of the synthesis of one of the more active boronated nucleosides, 2′‐deoxycytidine‐^3^N‐cyanoborane with a ^14^C‐label in the 2‐position of the pyrimidine ring.

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