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Synthesis of [14C]zolpidem

✍ Scribed by John Allen; André Tizot

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
259 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis of [I4 C ] Zolpidem, a new hypnotic agent having a non-benzodiazepine structure, is described. This compound was synthesised in a 64% overall radiochemical yield from potassium ["C]cyanide and with a specific radioactivity of 56 mCi/mmol. I t was used for pharmacokinetic and drug metabolism studies.

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