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Synthesis of 14C-labelled compounds. II. Synthesis of 14C-methylacetoxy methylnitrosamine

✍ Scribed by Horst Braun; Manfred Wiessler

Publisher: John Wiley and Sons
Year: 1977
Tongue: French
Weight: 242 KB
Volume: 13
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580130313

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✦ Synopsis

Abstract

1,3,5–^14^C‐trimethylhexahydro‐1,3,5‐triazine was prepared by condensing ^14^C‐methylamine‐hydrochloride and formaldehyde in a concentrated aqueous solution. The so formed triazine reacts with Nitrosylchloride at 0°C to ^14^C‐methylchlorarethylnitrosamine which was not isolated and reacted further with silver acetate. After column chromatography on Silica gel and distillation ^14^C‐methylacetoxymethylnitrosamine was obtained in a 24.1% yield based on ^14^C‐methylamine‐hydrochloride.

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