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Synthesis of 14C-Labelled Cefclidin (E1040)

✍ Scribed by Isao Sugiyama; G. T. Woolley; Hitoshi Mizuo; Hiroshi Yamauchi

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 274 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310905

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✦ Synopsis

Abstract

Cefclidin (E1040), a new injectable cephalosporin with potent antipseudomonal activity, was synthesized labelled with carbon‐14, starting from bromo[1‐^14^C]acetic acid according to the method illustrated in Scheme 1, 2. [^14^C] Cefclidin, having a specific activity of 3.43 MBq/mg (water content 15.3%, which was based on water content of non labelled compound prepared by the same procedure), was obtained in 2% overall radiochemical yield, with a radiochemical purity of more than 99.1%.

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