✦ LIBER ✦

Synthesis of 14C-labeled E4010

✍ Scribed by N. Watanabe; T. Tokumura; T. Nakamura

Publisher: John Wiley and Sons
Year: 2001
Tongue: French
Weight: 74 KB
Volume: 44
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.509

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

^14^C‐Labeled E4010, [4‐(3‐chloro‐4‐methoxybenzyl)amino‐1‐(4‐hydroxy) ‐piperidino]‐6‐[4‐^14^C]phthalazinecarbonitrile monohydrochloride was synthesized for drug metabolism and pharmacokinetic studies using [1‐chloro‐4‐(3‐chloro‐4‐methoxybenzyl)amino]‐6‐[4‐^14^C]phthalazinecarbonitrile as the starting material. The radiochemical yield was 33.4%. The specific radioactivity and radiochemical purity, as determined by radio‐HPLC and LSC, were 4.77 MBq/mg and 99.8%, respectively. Copyright © 2001 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Synthesis of 14C-Labelled Cefclidin (E10

Synthesis of 14C-Labelled Cefclidin (E1040)

✍ Isao Sugiyama; G. T. Woolley; Hitoshi Mizuo; Hiroshi Yamauchi 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 274 KB

## Abstract Cefclidin (E1040), a new injectable cephalosporin with potent antipseudomonal activity, was synthesized labelled with carbon‐14, starting from bromo[1‐^14^C]acetic acid according to the method illustrated in Scheme 1, 2. [^14^C] Cefclidin, having a specific activity of 3.43 MBq/mg (wate

Synthesis of 14C-labeled aminoglutethimi

Synthesis of 14C-labeled aminoglutethimide

✍ Naba K. Chaudhuri; Ofelia Servando; Ming-Sang Sung; Heinz Baumann 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 367 KB

A new procedure has been developed for the synthesis of I4C-labeled glutethimide with an improved yield from K14CN. In this procedure benzyl cyanide prepared from benzyl chloride and K14CN was almost quantitatively monoethylated by an ion-pair extraction method using 50% excess of tetrabutylammonium

Synthesis of 14C-labeled bunolol

✍ Edward J. Merrill 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 English ⚖ 385 KB

Ring-labeled bunolol, df -5 -[3 -(tertbutylamino) -2-hydroxypropoxyJ-3,Cdihydro-l(2ti)-naphthalenone-l-~4C, was synthesized in several steps by initially allowing 3-phenylpropylmag-lJ4C acid was cyclized to a-tetralone-lJ4C. The ring was then oxidized and opened to 4-(2-hydroxyphenyl)butyri~l-~~C ac

Synthesis of 14C-labelled sodium paripra

Synthesis of 14C-labelled sodium pariprazole (E3810)

✍ Katsuya Tagami; Shigeru Chiku; Shigeru Sohda 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 206 KB 👁 1 views

## Abstract Sodium pariprazole (E3810), an inhibitory of H^+^,K^+^‐ATPase, was synthesized labelled with carbon‐14, starting from 2‐mercapto[2‐^14^C]‐benzimidazole 1 with a specific activity of 888 MBq/mmol. It was obtained in 49.3% radiochemical yield with a radiochemical purity of more than 98%.

Synthesis of 14C-labeled levamisole and

Synthesis of 14C-labeled levamisole and 13C-labeled tetramisole

✍ V. J. Feil 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 275 KB 👁 2 views

The syntheses of '%-ring labeled levamisole ([-)-2,3,5,6-tetrahydr0-6-phenyl[~'C-UL]imidazo(Z, 1b]thiole) from acetophenone-ring-UL-l'C in 5 steps plus resolution with a 7.5% overall yield, and %,-ring labeled tetramisole ([i]-2,3,5,6-tetrahydro-6-phenyif3 S ]imidaz0[2,?-bjthiazole) from benzene-'%,

Synthesis of 14C-labeled FAD-C44

✍ Christopher Bieniarz; Kornepati V. Ramakrishna; Terence P. Kelly 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 192 KB 👁 2 views