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Synthesis of 14C-labeled perfluorooctanoic and perfluorodecanoic acids; purification of perfluorodecanoic acid

✍ Scribed by Ieva L. Reich; Hans J. Reich; Lawrence A. Menahan; Richard E. Peterson

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
397 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

Perf1 uoro-n-octanoic acid (PFOA) and perf luoro-n-decanoic acid (PFOA), two yddely used industrial products, have been synthesized with C-labeling in the C-1 position. The carboxyl labeled materials were prepared in 48% and 53% yield by carbonation of perfluoroheptyllithium and perfluorononyllithium at -100°C. An efficient chemical method for purification of PFDA was also developed. Treatment of commercial PFDA with refluxing potassium hydroxide solution resulted in removal of the m n o and diprotio impurities to give 99% pure PFDA.

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