𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 14C-labeled indeloxazine hydrochloride (YM-08054), a cerebral activator

✍ Scribed by Hideki Arima; Kazuharu Tamazawa

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
388 KB
Volume
22
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Indel oxazi ne hydrochloride, (f ) -2-[( i nden-7-yl oxy)methyl]morphol ine hydrochloride (YM-08054), a new cerebral activator, was labeled w i t h 14C f o r metabolic studies. The labeled material with a s p e c i f i c a c t i v i t y o f 14.9 mCi/mmol was synthesized i n a 42.8% radiochemical y i e l d from potassium [ Clcyanide via a process o f ten steps.

📜 SIMILAR VOLUMES

Synthesis of [14C]ABT-418, a cholinergic
Synthesis of [14C]ABT-418, a cholinergic channel activator labeled at two sites on the isoxazole ring
✍ Bruce W. Surber; Richard L. Elliott; Hana Kopecka; Samuel B. Thomas 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 283 KB

14C]ABT-418, (S)-3-[~4C]methyl-5-[N-methyl-2-pyrmlidinyl][4-14C]isoxazole hydrochloride, was labeled in two positions at maximum specific activity. Starting with 100 mCi of sodium 12-14Clacetate. 14.6 mCi at 105 mCi/mmol was obtained in 8 steps including the formation of [1.3-14CIacetone in the pyro

Potential drugs labelled with 14C. I. Th
Potential drugs labelled with 14C. I. The synthesis of 3-benzylamino-5, 6-dihydro-8, 9-dimethoxy-imidazo [5,1-a] isoquinoline hydrochloride
✍ G. Zólyomi; E. Koltai; D. Bánfi; K. Harsányi 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 434 KB

## Abstract 3‐Benzylamino‐8, 9‐dimethoxy‐5, 6‐dihydro‐imidazo‐ [5,1‐a] isoquinoline hydrochloride was labelled with ^14^C in two different positions: In one case the ^14^C was built into the position 2 of the imidazole ring, in the other case into the position 3 of the isoquinoline ring. In the fir

Potential drugs labelled with 14C. II. S
Potential drugs labelled with 14C. II. Synthesis of 1-cyano-3-imino-8, 9-dimethoxy-3, 4,5,6- -tetrahydro-thiazolo[4, 3-a]isoquinoline hydrochloride
✍ E. Koltai; G. Zólyomi; P. Komáromy; D. Bánfi; T. Szüts; K. Takács 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 295 KB

## Abstract The synthesis of 1‐cyano‐3‐imino‐8,9‐dimethoxy‐ ‐3,4, 5,6‐tetrahydro‐thiazolo [4,3‐a]isoquinoline hydrochloride labelled with ^14^C in five different positions: in position 3 (**1a**), in the cyano group at position 1 (**1b**), in position 5 (**1c**), in position 10b (**1d**) and in the