Synthesis of 14C-coniferyl alcohol (4-hydroxy-3-methoxycinnamyl alcohol)
β Scribed by H. M. Balba; Gerald G. Still
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 403 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Radiolabeled 4βhydroxycoumarin was synthesized on a microscale by condensing [Uβ^14^C]phenol and malonic acid in the presence of anhydrous zinc chloride and phosphorus oxychloride. The yield was 14% on a 0.5 mmol scale at a specific activity of 107 ΞΌCi/mmol.
Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co