## Abstract The synthesis of selectively ^14^C‐labeled l‐tryptophan and its derivative 5‐hydroxy‐l‐tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1‐^14^C[‐dl‐alanine, indole or 5‐hydroxyindole has been converted to [1‐^14^C]‐l‐tryptophan or 5′‐hydroxy‐[1‐^
Synthesis of [3-14C]-L-tryptophan and 5′-hydroxy-[3-14C]-L-tryptophan
✍ Scribed by E. Winnicka; M. Kańska
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 195 KB
- Volume
- 280
- Category
- Article
- ISSN
- 1588-2780
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The title compounds were synthesized starting from dimethyl (2S,3aR,8aS)‐(+)‐8‐(phenylsulfonyl)hexahydrophyrrolo[2,3‐b]indole‐1,2‐dicarboxylate. This compound on treatment with LDA followed by reaction with [^14^C]methyl iodide or [^3^H]methyl iodide gave the methyl substituted derivati
A practical method for the preparation of large amounts of enantiomerically pure alpha-[14C]methyl-L-tryptophan using the enzymatic resolution of the corresponding D,L-methyl ester is reported. The radiolabelled alpha-methyl group was introduced using the alpha-methylation of the lithium enolate of