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Synthesis of 14-methyl[2,3-3H]hexadecanoic acid

✍ Scribed by O. Helmich; M. Streibl; J. Filip; J. Hradec

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 285 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220907

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✦ Synopsis

14-MethylC2, 3-3Hlhexadecanoic acid of a specific radioactivity of 5 1 Ci/mmol was pepared starting from 12-methyltetradecanoic acid isolated from wool fat. This fatty acid was converted into 12-methyltetradecanal which was reacted with ethyl diethylphosphonoacetate to yield 14-methylhexadecen-2-oic acid. "he resulting compound was tritiated with gaseous ' H 2 in the presence of a 5s Pd/BaS04 catalyst.

The reaction in dried dioxane gave products of a specific radioactivity corresponding to 87.9% of the theoretical value.

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