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Synthesis of [13C7]3,5-dichlorobenzylamine hydrochloride

✍ Scribed by Simon J. Harwood

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
88 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Commercially available [^13^C~6~]aniline (2) was readily converted into [^13^C~6~]1‐bromo‐3,5‐dichlorobenzene (5). A further stable label was introduced by cyanation of aryl bromide (5), using K^13^CN and cuprous iodide. Borane reduction of benzonitrile (6), followed by an acid work up, furnished [^13^C~7~]3,5‐dichlorobenzylamine hydrochloride (1), which was further elaborated to provide an internal standard for use in LC‐MS assays. Copyright © 2004 John Wiley & Sons, Ltd.

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