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Synthesis of [11C]-3-quinuclidinylbenzilate (QNB)

✍ Scribed by C. Prenant; L. Barre; C. Crouzel

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 257 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580271104

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✦ Synopsis

A method is described by which 1.11 to 1.48 GBq (30 to 40 mCi) of ["CIQNB can be obtained from approximately 55.5 GBq (1.5 Ci) of llCO, in 40 minutes.

The product, purified by HPLC chromatogaphy, is obtained with a specific activity of 18.5 to 3 3 . 3 GBq/umol (500 to 9 0 0 mCi/vmol).

Carbon-11 labelling is performed in two stages :

-Formation of ["Clbenzilic acid by carbonation by "CO, of the the pre-prepared benzophenone dianion.

-Esterification of [llC]benzilic acid by 3-quinuclidinol in the presence of carbonyldiimidazole.

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