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Synthesis of 1-alkoxy-5-alkyluracils

✍ Scribed by Dae-Kee Kim; Ganghyeok Kim; Jinsoo Lim; Key H. Kim


Book ID
112131377
Publisher
Journal of Heterocyclic Chemistry
Year
1995
Tongue
English
Weight
374 KB
Volume
32
Category
Article
ISSN
0022-152X

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πŸ“œ SIMILAR VOLUMES


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## Abstract Synthesis of 6‐substituted 1‐alkoxy‐5‐alkyluracils 2a‐c have been achieved from readily accessible 2‐alkyl‐3,3‐di(methylthio)acryloyl chlorides 4a,b in high overall yields. Treatment of 4a,b with silver cyanate followed by reaction of the resulting isocyanates 5a,b with an appropriate a

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Many naturally occurrinq as well as synthetic nucleosides are known to manifest a variety of bioloqical activities (l-3) . Very often these compounds are pyrimidine type analoques of the normal nucleic acid constituents in which the C-5, C-6 double bond has been functionalized. Thus several C-S subs