Synthesis of 1-alkoxy-5-alkyluracils
β Scribed by Dae-Kee Kim; Ganghyeok Kim; Jinsoo Lim; Key H. Kim
- Book ID
- 112131377
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1995
- Tongue
- English
- Weight
- 374 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-152X
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π SIMILAR VOLUMES
## Abstract Synthesis of 6βsubstituted 1βalkoxyβ5βalkyluracils 2aβc have been achieved from readily accessible 2βalkylβ3,3βdi(methylthio)acryloyl chlorides 4a,b in high overall yields. Treatment of 4a,b with silver cyanate followed by reaction of the resulting isocyanates 5a,b with an appropriate a
Many naturally occurrinq as well as synthetic nucleosides are known to manifest a variety of bioloqical activities (l-3) . Very often these compounds are pyrimidine type analoques of the normal nucleic acid constituents in which the C-5, C-6 double bond has been functionalized. Thus several C-S subs