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FACILE LARGE SCALE SYNTHESIS OF 5-ALKYLURACILS

✍ Scribed by Koroniak, Henryk; Jankowski, Aleksander; Krasnowski, Miroslaw


Book ID
118159469
Publisher
Taylor and Francis Group
Year
1993
Tongue
English
Weight
328 KB
Volume
25
Category
Article
ISSN
0030-4948

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## Abstract Synthesis of 6‐substituted 1‐alkoxy‐5‐alkyluracils 2a‐c have been achieved from readily accessible 2‐alkyl‐3,3‐di(methylthio)acryloyl chlorides 4a,b in high overall yields. Treatment of 4a,b with silver cyanate followed by reaction of the resulting isocyanates 5a,b with an appropriate a