New synthesis of 5,6-cyclothymine- and 6-alkyluracil-1-N-β-D-ribosides
✍ Scribed by Jean-Louis Fourrey; Gérard Henry; Patrick Jouin
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 213 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Many naturally occurrinq as well as synthetic nucleosides are known to manifest a variety of bioloqical activities (l-3) . Very often these compounds are pyrimidine type analoques of the normal nucleic acid constituents in which the C-5, C-6 double bond has been functionalized. Thus several C-S substituted uracil and cytosine (deoxy-) ribosides are antiviral agents (4) .
📜 SIMILAR VOLUMES
The allylic alcohol in ribose-protected zeatin riboside 1, was oxidised to an aldehyde by barium manganate. Heating of the resulting aldehyde in chloroform allowed the cyclizatiin of the N%hain into a 3methylpyrrole ring. After deprotection of the ribose, the title compound was obtained and identifi
The treatment of derivatives of 1,6-epithio-and 1,6-episeleno-/3-D-glucopyranose with various carbohydrate alcohols in the presence of N-iodosuccinimide/triflic acid gives rise to disulfides and diselenides, respectively, which may be transformed to the desired 6-deoxy-fl-D-glucopyranosides.