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Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2- exo -2-(2‘-Substituted-3‘-phenyl-5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel Nicotinic Antagonist

✍ Scribed by Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernán A.; Brieaddy, Lawrence E.; Abraham, Philip; Damaj, M. I.; Martin, Billy R.


Book ID
127231534
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
42 KB
Volume
44
Category
Article
ISSN
0022-2623

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✍ Andrew Horti; Hayden T. Ravert; Edythe D. London; Robert F. Dannals 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 585 KB

The radiochemical synthesis of (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl)-7azabicyclo[2.2. llheptane ([W'lI\_) was accomplished by Kryptofixa 222 assisted nucleophilic no-carrier-added [18F]fluorination of (+/-)-exo-2-(2-bromo-5-pyridyl)-7-azabicyclo[2.2.1] heptane (h). The average radiochemical yield of