✦ LIBER ✦

Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: (+/−)-exo-2-(2-[18F]fluoro-5-pyridyl)-7-azabicyclo[2.2.1]heptane

✍ Scribed by Andrew Horti; Hayden T. Ravert; Edythe D. London; Robert F. Dannals

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 585 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199604)38:4<355::aid-jlcr842>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

The radiochemical synthesis of (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl)-7azabicyclo[2.2. llheptane ([W'lI_) was accomplished by Kryptofixa 222 assisted nucleophilic no-carrier-added [18F]fluorination of (+/-)-exo-2-(2-bromo-5-pyridyl)-7-azabicyclo[2.2.1] heptane (h). The average radiochemical yield of the final product was 10% and the average specific activity was greater than >2000 mCVpmo1, calculated at end-ofsynthesis. The stable fluorine ligand ([19E71) was prepared by Kryptofixa 222 assisted nucleophilic fluorination of (+/-)-exo-2-(2bromo-5-pyridyl) -7methoxycarbonyl -7azabicyclo[2.2. llheptane (a) followed by acid deprotection.

📜 SIMILAR VOLUMES

Synthesis of a radiotracer for studying

Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: 2-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-[18F]A-85380)

✍ Andrew G. Horti; Andrei O. Koren; Hayden T. Ravert; John L. Musachio; William B. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 568 KB

ChemInform Abstract: Synthesis and Nicot

ChemInform Abstract: Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo-2-(2′-Fluoro-5′-pyridinyl)-7-azabicyclo(2.2.1)heptane: A New Positron Emission Tomography Ligand for Nicotinic Receptors.

✍ F. LIANG; H. A. NAVARRO; P. ABRAHAM; P. KOTIAN; Y.-S. DING; J. FOWLER; N. VOLKOW 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Synthesis of a radioiodinated analog of

Synthesis of a radioiodinated analog of epibatidine: (±)-exo-2-(2-iodo-5-pyridyl)-7-azabicyclo[2.2.1]heptane for in vitro and in vivo studies of nicotinic acetylcholine receptors

✍ John L. Musachio; Andrew Horti; Edythe D. London; Robert F. Dannals 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 573 KB

Radiosynthesis of 2-exo-(2′-[18F]Fluoro-

Radiosynthesis of 2-exo-(2′-[18F]Fluoro-3′-(4-fluorophenyl)-pyridin-5′-yl)-7-azabicyclo[2.2.1]heptane ([18F]F2PhEP), a potent epibatidine-based radioligand for nicotinic acetylcholine receptor PET imaging

✍ Gaëlle Roger; Françoise Hinnen; Héric Valette; Wadad Saba; Michel Bottlaender; F 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 189 KB

2-exo-(2 0 -Fluoro-3 0 -(4-fluorophenyl)-pyridin-5 0 -yl)-7-azabicyclo[2.2.1]heptane (F 2 PhEP), a novel, epibatidine-based, a4b2-selective nicotinic acetylcholine receptor antagonist of low toxicity, as well as the corresponding N-Boc-protected chloro-and bromo derivatives as precursors for labelli

ChemInform Abstract: New Synthesis and E

ChemInform Abstract: New Synthesis and Evaluation of Enantiomers of 7-Methyl-2-exo-(3′-iodo-5′-pyridinyl)-7-azabicyclo[2.2.1]heptane as Stereoselective Ligands for PET Imaging of Nicotinic Acetylcholine Receptors.

✍ Yongjun Gao; Andrew G. Horti; Hiroto Kuwabara; Hayden T. Ravert; Daniel P. Holt; 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 24 KB 👁 2 views

ChemInform Abstract: exo-2-(Pyridazin-4-

ChemInform Abstract: exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: Syntheses and Nicotinic Acetylcholine Receptor Agonist Activity of Potent Pyridazine Analogues of (.+-.)-Epibatidine.

✍ Daqing Che; Thomas Wegge; Milton T. Stubbs; Gunther Seitz; Heinrich Meier; Chris 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views