𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of a radioiodinated analog of epibatidine: (±)-exo-2-(2-iodo-5-pyridyl)-7-azabicyclo[2.2.1]heptane for in vitro and in vivo studies of nicotinic acetylcholine receptors

✍ Scribed by John L. Musachio; Andrew Horti; Edythe D. London; Robert F. Dannals

Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
573 KB
Volume
39
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of a radiotracer for studying
Synthesis of a radiotracer for studying nicotinic acetylcholine receptors: (+/−)-exo-2-(2-[18F]fluoro-5-pyridyl)-7-azabicyclo[2.2.1]heptane
✍ Andrew Horti; Hayden T. Ravert; Edythe D. London; Robert F. Dannals 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 585 KB

The radiochemical synthesis of (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl)-7azabicyclo[2.2. llheptane ([W'lI\_) was accomplished by Kryptofixa 222 assisted nucleophilic no-carrier-added [18F]fluorination of (+/-)-exo-2-(2-bromo-5-pyridyl)-7-azabicyclo[2.2.1] heptane (h). The average radiochemical yield of

[125/123I]IPH: A radioiodinated analog o
[125/123I]IPH: A radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors
✍ John L. Musachio; Victor L. Villemagne; Ursula Scheffel; Marigo Stathis; Paige F 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB 👁 1 views

Tomographic imaging of central nicotinic acetylcholine receptors (nAChRs) via single photon emission computed tomography (SPECT) has been hampered by the lack of a radioligand with suitable in vivo binding characteristics. Therefore, a novel analog of epibatidine, (6)-exo-2-(2-iodo-5-pyridyl)-7-azab

Radiosynthesis of 2-exo-(2′-[18F]Fluoro-
Radiosynthesis of 2-exo-(2′-[18F]Fluoro-3′-(4-fluorophenyl)-pyridin-5′-yl)-7-azabicyclo[2.2.1]heptane ([18F]F2PhEP), a potent epibatidine-based radioligand for nicotinic acetylcholine receptor PET imaging
✍ Gaëlle Roger; Françoise Hinnen; Héric Valette; Wadad Saba; Michel Bottlaender; F 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 189 KB

2-exo-(2 0 -Fluoro-3 0 -(4-fluorophenyl)-pyridin-5 0 -yl)-7-azabicyclo[2.2.1]heptane (F 2 PhEP), a novel, epibatidine-based, a4b2-selective nicotinic acetylcholine receptor antagonist of low toxicity, as well as the corresponding N-Boc-protected chloro-and bromo derivatives as precursors for labelli