Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2‘,3‘-Disubstituted 5‘-pyridinyl)-7-azabicyclo[2.2.1]heptanes: Epibatidine Analogues
✍ Scribed by Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernán A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj, M. I.; Martin, Billy R.
- Book ID
- 111869157
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 104 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-2623
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2-exo-(2 0 -Fluoro-3 0 -(4-fluorophenyl)-pyridin-5 0 -yl)-7-azabicyclo[2.2.1]heptane (F 2 PhEP), a novel, epibatidine-based, a4b2-selective nicotinic acetylcholine receptor antagonist of low toxicity, as well as the corresponding N-Boc-protected chloro-and bromo derivatives as precursors for labelli