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Synthesis and Nicotinic Acetylcholine Receptor Binding Properties of exo -2-(2‘-Fluoro-5‘-pyridinyl)-7-azabicyclo- [2.2.1]heptane: A New Positron Emission Tomography Ligand for Nicotinic Receptors

✍ Scribed by Liang, Feng; Navarro, Hernán A.; Abraham, Philip; Kotian, Pravin; Ding, Yu-Shin; Fowler, Joanna; Volkow, Nora; Kuhar, Michael J.; Carroll, F. Ivy


Book ID
125942233
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
103 KB
Volume
40
Category
Article
ISSN
0022-2623

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The radiochemical synthesis of (+/-)-exo-2-(2-[18F]fluoro-5-pyridyl)-7azabicyclo[2.2. llheptane ([W'lI\_) was accomplished by Kryptofixa 222 assisted nucleophilic no-carrier-added [18F]fluorination of (+/-)-exo-2-(2-bromo-5-pyridyl)-7-azabicyclo[2.2.1] heptane (h). The average radiochemical yield of