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Synthesis, DNA-Binding and Photocleavage Studies of the Ruthenium(II) Complexes [Ru(phen)2(ppd)]2+ and [Ru(phen)(ppd)2]2+ (ppd=Pteridino[6,7-f] [1,10]phenanthroline-11,13(10H,12H)-dione, phen=1,10-Phenanthroline)

✍ Scribed by Feng Gao; Hui Chao; Yuan-Fang Wei; Yi-Xian Yuan; Bin Peng; Xin Chen; Kang-Cheng Zheng; Liang-Nian Ji

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
517 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two new complexes, [Ru(phen)~2~(ppd)]^2+^ (1) and [Ru(phen)(ppd)~2~]^2+^ (2) (ppd=pteridino[6,7‐f] [1,10]phenanthroline‐11,13(10__H__,12__H__)‐dione, phen=1,10‐phenanthroline) were synthesized and characterized by ES‐MS, ^1^H‐NMR spectroscopy, and elemental analysis. The intercalative DNA‐binding properties of 1 and 2 were investigated by absorption‐spectroscopy titration, luminescence‐spectroscopy studies, thermal denaturation, and viscosity measurements. The theoretical aspects were further discussed by comparative studies of 1 and 2 by means of DFT calculations and molecular‐orbital theory. Photoactivated cleavage of pBR322 DNA by the two complexes were also studied, and 2 was found to be a much better photocleavage reagent than 1. The mechanism studies revealed that singlet oxygen and the excited‐states redox potentials of the complex may play an important role in the DNA photocleavage.

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