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Synthesis, Characterization, and DNA-Binding Properties of the Chiral Ruthenium(II) Complexes Δ- and Λ-[Ru(bpy)2(dmppd)]2+ (dmppd = 10,12-Dimethylpteridino[6,7-f] [1,10]phenanthroline-11,13(10H,12H)-dione; bpy = 2,2′-Bipyridine)

✍ Scribed by Feng Gao; Hui Chao; Feng Zhou; Lian-Cai Xu; Kang-Cheng Zheng; Liang-Nian Ji

Publisher: John Wiley and Sons
Year: 2007
Tongue: German
Weight: 255 KB
Volume: 90
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200790019

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✦ Synopsis

Two novel chiral ruthenium(II) complexes, D-[Ru(bpy

10,12-dimethylpteridino[6,7-f] [1,10]

phenanthroline-11,13(10H,12H)-dione, bpy = 2,2'-bipyridine), were synthesized and characterized by elemental analysis, 1 H-NMR and ES-MS. The DNA-binding behaviors of both complexes were studied by UV/VIS absorption titration, competitive binding experiments, viscosity measurements, thermal DNA denaturation, and circular-dichroism spectra. The results indicate that both chiral complexes bind to calf-thymus DNA in an intercalative mode, and the D enantiomer shows larger DNA affinity than the L enantiomer does. Theoretical-calculation studies for the DNA-binding behaviors of these complexes were carried out by the density-functional-theory method. The mechanism involved in the regulating and controlling of the DNA-binding abilities of the complexes was further explored by the comparative studies of [Ru(bpy) 2

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