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Synthesis, Characterization, and DNA-Binding Properties of the Ruthenium(II) Complexes [Ru(dipn)(dptp)](ClO4)2 and [Ru(dipn)(pat)](ClO4)2 (dipn=N-(3-Aminpropyl)propane-1,3-diamine; dptp=2-(5,6-Diphenyl-1,2,4-triazin-3-yl)-1,10-phenanthroline; pat=9-(1,10-Phenanthrolin-2-yl)acenaphtho[1,2-e][1,2,4]triazine)

✍ Scribed by Xian-Lan Hong; Hui Chao; Li-Jun Lin; Kang-Cheng Zheng; Hong Li; Xiang-Li Wang; Feng-Cun Yun; Liang-Nian Ji

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
253 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two novel tridentate ruthenium(II) complexes containing an asymmetric heteroaromatic and a polyamine ligand, Ru(dipn)(dptp)~2~ (1⋅2 $\rm{ ClO_4^ -}$) and Ru(dipn)(pat)~2~ (2⋅2 $\rm{ ClO_4^ -}$) (dipn=N‐(3‐aminopropyl)propane‐1,3‐diamine; dptp=2‐(5,6‐diphenyl‐1,2,4‐triazin‐3‐yl)‐1,10‐phenanthroline; and pat=9‐(1,10‐phenanthrolin‐2‐yl)acenaphtho[1,2‐e][1,2,4]triazine) were synthesized and characterized by elemental analysis, ESI‐MS, ^1^H‐NMR, UV/VIS, and cyclic voltammetry. The DNA‐binding behavior of both complexes was studied by absorption titration, thermal denaturation, and viscosity measurements. Results indicate that complex 2 binds to calf‐thymus DNA in an intercalative mode but complex 1 binds to DNA in partial intercalation, and the DNA**‐**binding affinity of complex 2 is much greater than that of complex 1. Theoretical studies for these complexes were also carried out with the density‐functional‐theory (DFT) method. The trend in the DNA‐binding affinity and some electrochemical and spectral properties of the complexes can be further explained applying the DFT computational results.

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