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Synthesis, characterization, and in vitro antimicrobial and antitumor activities of some tetraphenylstibonium(V) carboxylates

✍ Scribed by Kiran Singhal; Rahul Mishra; Prem Raj

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
104 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

Several hitherto unreported pentacoordinated tetraphenylstibonium(V) carboxylates of general formula (C~6~H~5~)~4~SbL, where L = o‐OHC~6~H~5~COOο£Ώ, (C~6~H~5~)~2~C(OH)COOο£Ώ, 2‐(6‐OCH~3~C~10~H~6~)CH(CH~3~)COOο£Ώ, ArCH(OH)COOο£Ώ (Ar = C~6~H~5~, p‐CF~3~C~6~H~4~, and __p__ο£ΏOCH~3~C~6~H~4~), have been prepared and characterized by elemental analysis, solid state IR, ^1^H NMR, and ^13^C NMR spectra, conductivity, and molecular weight measurements. Spectroscopic data together with solution phase studies conform to the requirement of triagonal‐bipyramidal configuration for these compounds. They were tested for in vitro antifungal (against Aspergillus flavus and Aspergillus niger) and antibacterial (against Staphylococcus aureus and Klebsiella pneumoniae) activities. The in vitro antitumor activity of all stibonium carboxylates was examined against MCF‐7 cell line. A few of them were found to exhibit moderate to significant biological activity. Β© 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:688–693, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20498

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