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Synthesis, characterization and anticancer activity of new palladacycles derived from chiral α-diimines

✍ Scribed by Sandra Cruz; Sylvain Bernès; Pankaj Sharma; Rosa Vazquez; Guadalupe Hernández; Roberto Portillo; René Gutiérrez

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
122 KB
Volume
24
Category
Article
ISSN
0268-2605

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✦ Synopsis

Abstract

Optically pure α‐diimines quantitatively obtained in solvent‐free conditions starting from 2,3‐butanedione and (S)‐(−)‐1‐phenylethylamine and (S)‐(−)‐1‐(4‐methylphenyl)ethylamine, respectively, yielded the new chiral mono‐Pd complexes 2a–b, which have been partly characterized by IR, ^1^H‐ and ^13^C‐NMR spectroscopies along with MS‐FAB^+^ spectrometry. The crystal and molecular structure for palladacycle 2a has been fully confirmed by single‐crystal X‐ray studies. Studies in vitro of 2a–b have displayed growth inhibition against different classes of cancer: leukemia (K‐562 CML), colon cancer (HCT‐15), breast cancer (MCF‐7), central nervous system (U‐251 Glio) and prostate cancer (PC‐3) cell lines. Copyright © 2009 John Wiley & Sons, Ltd.

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