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Synthesis, Antimicrobial and Anticancer Activity of New Thiosemicarbazone Derivatives

✍ Scribed by Umasankar Kulandaivelu; Valisakka Gari Padmini; Kyatham Suneetha; Boyapati Shireesha; Jannu Vincent Vidyasagar; Tadikonda Rama Rao; Jayaveera K N; Arijit Basu; Venkatesan Jayaprakash

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
131 KB
Volume
344
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

Thiosemicarbazones of p‐aminobenzoic acid (PABA) were synthesized and tested for their antimicrobial and anticancer activity. Hydroxamate derivatives 4a–4l were found to have better antimicrobial and anticancer activity than their acid counterpart. Compound 4d was found to have good antimicrobial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio cholerae, and Bacillus subtilis with IC~50~ value of about 1 µM. Compound 4f showed potent antifungal activity against Candida albicans (IC~50~ = 1.29 µM) and compound 4h showed potent anticancer activity (IC~50~ = 0.07 µM).

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