Synthesis, Biophysical, and Biochemical Properties of PNA-DNA Chimeras
β Scribed by Zoltan Bajor; Gyula Sagi; Zsuzsanna Tegyey; Laszlo Oetvoes
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 56 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Peptide nucleic acids (PNAs) are oligonucleotide mimics in which the sugar-phosphate backbone has been replaced by a pseudo-peptide backbone. Among PNA-based molecules, PNA-DNA conjugates characterized by tracts of DNA bound to N and/or C terminus of PNA are very soluble in aqueous media, are able t
## Abstract A new synthetic strategy to get the PNAβ3β²DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed. The synthetic strategies