New synthesis of PNA–3′DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras

✍ Scribed by Domenica Musumeci; Giovanni N. Roviello; Margherita Valente; Roberto Sapio; Carlo Pedone; Enrico M. Bucci

• Publisher: Wiley (John Wiley & Sons)
• Year: 2004
• Tongue: English
• Weight: 112 KB
• Volume: 76
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.20135

✦ Synopsis

Abstract

A new synthetic strategy to get the PNA–3′DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed. The synthetic strategies take advantage of the introduction of the acid‐labile Mmt‐protecting group in the first step. © 2004 Wiley Periodicals, Inc. Biopolymers (Pept Sci), 2004