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Synthesis, antiviral activity and enzymatic phosphorylation of 9-phosphonopentenyl derivatives of guanine

✍ Scribed by Jean-François Navé; Debra Taylor; Stan Tyms; Michael Kenny; Anne Eggenspiller; Anne Eschbach; Jacqueline Dulworth; Tara Brennan; François Piriou; Serge Halazy

Book ID
113259061
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
931 KB
Volume
27
Category
Article
ISSN
0166-3542

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The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inh