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Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine

✍ Scribed by Jean-François Navé; Patrick J. Casara; Debra L. Taylor; A. Stanley Tyms; Michael Kenny; Serge HalazyS

Book ID
103983236
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
286 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.

In recent years, numerous acyclonucleotide analogues have been prepared as potential antiviral agents 1-6.

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