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Synthesis, anti-microbial evaluation, and molecular modeling of new pyrazolo[3,4-d]pyrimidine derivatives

โœ Scribed by Ahmad F. Eweas, S. A. Swelam, O. A. Fathalla, N. M. Fawzy, Sh. I. Abdel-Moez


Book ID
118778053
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
494 KB
Volume
21
Category
Article
ISSN
1054-2523

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A convenient synthesis of pyrazolo[3,4-d
โœ M. El Haddad; M. Soukri; S. Lazar; A. Bennamara; G. Guillaumet; M. Akssira ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 470 KB

## Abstract Pyrazoloโ€[3,4โ€__d__]pyrimidineโ€4,6โ€diones **5** and pyrazolo[4,3โ€__d__]pyrimidineโ€5,7โ€diones **7** were synthesized by Curtius rearrangement of pyrazolic monoโ€esters **2** and **3** followed by heteroโ€cyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.